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Anti-cd43 antibody and use thereof for cancer treatment
专利权人:
APROGEN KIC INC.
发明人:
Hong, Kwon Pyo,Yoon, Sangsoon,Koukoulas, Irene,Cristiano, Briony,Wilson Jr, David S,Kopsidas, George,Vincent Batori
申请号:
NZ74157316
公开号:
NZ741573A
申请日:
2016.10.12
申请国别(地区):
NZ
年份:
2019
代理人:
摘要:
The present invention relates to an antibody for cancer treatment and provides an anti-CD43 antibody which binds an extracellular region of CD43 consisting of 6-9 amino acids in the amino acid sequence EGSPLWTSI, an anti-cancer composition and a composition for inhibiting cancer stem cells comprising the anti-CD43 antibody as an active ingredient, and a method for screening a cancer stem cell inhibitor. The anti-CD43 antibody comprises: heavy chain CDRs according to GYXMN (wherein X is F or Y), RINPNXGDSFYNQKFXG (wherein the first X is N or S; and the second X is Q or K), and EGYYGGRGYALDY; and light chain CDRs according to RTSQDISNYLN, XTXRLHS (wherein the first X is N, Q or A; and the second X is S or A), and QQSNMFPY.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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