Polypeptides, nucleic acids and uses thereof

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专利权人:

AGENCY FOR SCIENCE; TECHNOLOGY AND RESEARCH

发明人:

Bruno Reversade

申请号：

US15865950

公开号：

US10689428B2

申请日:

2018.01.09

申请国别(地区):

US

年份:

2020

代理人:

摘要：

We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence selected from the group consisting of: SEQ ID NO: 2 to SEQ ID NO: 18, preferably CLQRRCMPLHSRVPFP (SEQ ID NO: 2), or a fragment, homologue, variant or derivative thereof, which polypeptide is capable of maintaining self-renewal and/or pluripotency of a stem cell.

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