SOARES MELINA M,RAN SOPHIA,HE JIN,HUANG XIANMING,THORPE PHILIP E
申请号：
NZ61138703
公开号：
NZ611387A
申请日:
2003.07.15
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a composition comprising a purified antibody, or antigen-binding fragment or immunoconjugate thereof, wherein said antibody: (a) comprises a heavy chain variable region that includes the amino acid residues of the complementarity determining regions (CDRs) from amino acid positions 31-35 (CDR H1), 50-56 (CDR H2) and 95-102 (CDR H3) of SEQ ID NO:2 and a light chain variable region that includes the amino acid residues of the CDRs from amino acid positions 24-34 (CDR L1), 50-56 (CDR L2) and 89-97 (CDR L3) of SEQ ID NO:4 (b) binds to phosphatidylserine in an ELISA conducted in the presence of 10% serum and comprises a heavy chain variable region that includes the amino acid sequence of SEQ ID NO:2 or a light chain variable region that includes the amino acid sequence of SEQ ID NO:4 or (c) binds to phosphatidylserine in an ELISA conducted in the presence of 10% serum and comprises a heavy chain variable region that includes a variant or mutagenized form of the amino acid sequence of SEQ ID NO:2, wherein said variant or mutagenized form has at least about 96% amino acid sequence identity to the amino acid sequence of SEQ ID NO:2 and a light chain variable region that includes a variant or mutagenized form of the amino acid sequence of SEQ ID NO:4, wherein said variant or mutagenized form has at least about 96% amino acid sequence identity to the amino acid sequence of SEQ ID NO:4 and wherein said ELISA has the protocol as defined herein. Further disclosed is a composition comprising a chimeric antibody, wherein at least a first antigen binding region of the mouse monoclonal antibody 3G4, deposited as ATCC PTA 4545, is operatively attached to a human antibody constant region.
