GUOXIAN WU,KATRINA CHAN,TODD EWING,PRABHA N. IBRAHIM,JACK LIN,MARIKA NESPI,WAYNE SPEVAK,YING ZHANG
申请号：
ARP130105005
公开号：
AR094263A1
申请日:
2013.12.20
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: a compound of the formula (1) or a pharmaceutically acceptable Salt, solvate, taut\u00f3mero, a deuterated isomer, or an Analogue thereof, where: (i) r\u00b9 and R\u00b2 considered jointly form a FUSED Ring of 5 or 6 members optionally substituted Has between 0 - 3 heteroatoms, such as Ring members, selected from N, o or s,Where one or two carbon Atoms optionally Ring are replaced by - C (= o) - or (ii) r\u00b9 c\u2081\u208b\u2084 is H, alkyl, halogen, haloalquilo c\u2081\u208b\u2084, haloalcoxi c\u2081\u208b\u2084, ciclopropilo or a pair of unpaired electrons and is R\u00b2 - NH - L\u00b2 - r\u2076, where H is r\u2076, aryl optionally. Formed c\u2081\u208b\u2084 aryl alkyl, optionally substituted, optionally substituted heteroaryl,C\u2081\u208b\u2084 optionally substituted heteroaryl alkyl, optionally substituted alkyl c\u2081\u208b\u2086 heterocicloalquilo, optionally substituted cycloalkyl, optionally substituted alkyl, optionally substituted cicloalquil c\u2081\u208b\u2084, heterociclilo or optionally substituted alq heterociclil Uilo c\u2081\u208b\u2084 optionally substituted and where L\u00b2 is selected from a Link, - C (o) -, - C (o) n (r\u1da0) -, -, - so\u2082n (r\u1da0)- SO\u2082 -, - C (o) o -, - C (= nr\u1da0) n (r\u1da0), where each r\u1da0 independently is H or alkyl c\u2081\u208b\u2084 g is a c\u2081\u208b\u2086 optionally substituted alkyl, optionally substituted aryl or heteroaryl a 5 or 6 members optionally substituted with one or more Atoms Nitrogen, co Mo Ring members.Where the aryl or heteroaryl FUSED ring is optionally with a 5 to 8 members optionally replaced with 0-2 heteroatoms, such as Ring members, selected from o, N or s l\u00b9 is selected from - ch (OH) -, - C (o) nr\u2075 -, - ch\u2082n (r\u2075) -, -, - so\u2082n (r\u2075) N - (r\u2075) C (o) n (r\u2075) - N - (r\u2075) SO\u2082 -, - N (r\u2075 ch\u2082) - - - - - c\u2081\u208b\u2084 or rent, rent c\u2081\u208b\u2084 - or -, - C (o) - - - - nr\u2075c (OR), SO\u2082 -N - (r\u
