您的位置: 首页 > 农业专利 > 详情页

INHIBITEUR DU CANAL CALCIQUE DE TYPE T
专利权人:
KINKI UNIVERSITY;学校法人近畿大学;日本ケミファ株式会社;NIPPON CHEMIPHAR CO., LTD.
发明人:
TANAKA, Hiroto,田中博人,OOI, Isao,大井勲,SAITO, Daisuke,齊藤大祐,HAYASHIDA, Kohei,林田康平,YAMAMOTO, Kohei,山元広平,KAWABATA, Atsufumi,川畑篤史
申请号:
JPJP2019/028168
公开号:
WO2020/017569A1
申请日:
2019.07.17
申请国别(地区):
JP
年份:
2020
代理人:
摘要:
The purpose of the present invention is to provide a novel T-type calcium channel blocker. A compound represented by general formula (I), a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof or a solvate of the same is used as a T-type calcium channel blocker. (In the formula: A represents optionally substituted phenyl, a 4-6 membered heteroaryl ring consisting of, as ring-constituting atoms, 1-3 heteroatoms, said heteroatoms being the same or different and selected from an oxygen atom, a sulfur atom and a nitrogen atom, and carbon atom(s), or a hetero fused ring consisting of the heteroaryl ring and a benzene ring or a 6-membered heteroaryl ring consisting of 1-2 nitrogen atoms and carbon atoms (wherein the heteroaryl ring and the hetero fused ring are optionally substituted) and is bonded to the nitrogen atom of the adjacent cyclic amine through a carbon atom constituting the ring; B represents optionally substituted phenyl, a 5- or 6-membered heteroaryl ring consisting of, as ring-constituting atoms, 1-3 heteroatoms, said heteroatoms being the same or different and selected from an oxygen atom, a sulfur atom and a nitrogen atom, and carbon atoms, or a hetero fused ring consisting of the heteroaryl ring and a benzene ring or a 6-membered heteroaryl ring consisting of 1-2 nitrogen atoms and carbon atoms (wherein the heteroaryl ring and the hetero fused ring are optionally substituted) and is bonded to the adjacent cyclopropyl ring through a carbon atom constituting the ring; R1 and R2 may be either the same or different and represent a hydrogen atom, a halogen atom, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; n and m may be either the same or different and represent 0 or 1; and p represents 1 or 2.)L'objet de la présente invention est de fournir un nouveau inhibiteur du canal calcique de type T. L'invention concerne un composé représenté par la formule générale (I), un tautomère ou un stéréoisomère du composé, un sel
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充