Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt or stereoisomer of this, which is c\u2086\u208b\u2081\u2080: CY c\u2083\u208b\u2081\u2080 cycloalkyl, aryl,Heteroaryl 5 to 14 members or a heterocicloalquilo 4 to 10 members.Each of which is optionally substituted with 1 to 5 r\u2076 substituents selected independently or two adjacent substituents on the ring r\u2076 Cy,Taken together with the Atoms that are merged, forming a phenyl ring, a ring heterocicloalquilo 5, 6 or 7 members,FUSED heteroaryl Ring of 5 or 6 members or cycloalkyl Ring c\u2083\u208b\u2086 merged, where each heterocicloalquilo FUSED Ring 5,6 or 7 members and the Ring heteroaryl FUSED 5 or 6 members has 1 - 4 hetero Ring selected as members of N, o and S, and where each of the phenyl Ring FUSEDHeterocicloalquilo FUSED Ring 5, 6 or 7 members, ring heteroaryl FUSED Ring of 5 or 6 members and c\u2083\u208b\u2086 cycloalkyl, optionally substituted fused with 12 or 3 r\u1d47 substituents selected independently or two substituents attached to the same carbon Atom r\u2076 annular Cy, together with the carbon Atom to which it is coupled.Heterocicloalquilo form a Ring of 4, 5, 6 or 7 members c\u2083\u208b\u2086 cycloalkyl Ring or a ring, where each heterocicloalquilo 4, 56 or 7 members and the ring c\u2083\u208b\u2086 cycloalkyl optionally replaced with 1, 2 or 3 r\u1d47 substituents selected independently r\u00b9 is c\u2081\u208b\u2086 alkyl, Halo, alquenilo c\u2082\u208b\u2086,Alquinilo c\u2082\u208b\u2086, haloalquilo c\u2081\u208b\u2086, haloalcoxi c\u2081\u208b\u2086 c\u2086\u208b\u2081\u2080 cycloalkyl, aryl, heteroaryl c\u2083\u208b\u2081\u2080, 5 - 14 members, heterocicloalquilo 4 - 10 members c\u2086\u208b\u2081\u2080 alkyl -, aryl c\u2081\u208b\u2084,C\u2083\u208b\u2081\u2080 c\u2081\u208b\u2084 cycloalkyl alkyl - (heteroaryl 5 - 14 members c\u2081\u208b\u2084 - (alkyl) -, heterocicloalquilo 4 - 10 members) - alkyl - c\u2081\u208b\u2084, CN, no\u2082, or\u2077 sr\u2077 nh\u2
