Anti-activin A antibody and use thereof

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专利权人:

リジェネロン・ファーマシューティカルズ・インコーポレイテッド

发明人:

ジェスパー・グロマダ,エスター・ラトレス,アンドリュー・ジェイ・マーフィー,ジョージ・ディー・ヤンコプーロス,ロリ・シー・モートン

申请号：

JP2016531870

公开号：

JP6581085B2

申请日:

2014.07.30

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The present invention provides antibodies that bind to Activin A and methods of using the same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Activin A with high affinity. The antibodies of the invention are useful for the treatment of diseases and disorders characterized by decreased muscle mass or strength, such as sarcopenia, cachexia, muscle injury, muscle wasting/atrophy, cancer, fibrosis, and weight loss. The antibodies of the invention are also useful in combination with GDF8 binding proteins for the treatment of diseases and disorders characterized by decreased muscle mass or strength. The antibodies of the invention are also useful for the prevention, treatment, or amelioration of disorders and diseases caused by, promoted by, exacerbated by, and/or aggravated by Activin A, such as renal fibrosis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/