The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including inflammatory diseases and diseases associated with dysfunction of the central nervous system (CNS).本發明係關於結合至神經元菸鹼乙醯膽鹼受體且調節其活性的化合物,用於製備該等化合物的方法,包含該等化合物的醫藥組合物,及使用該等化合物以治療多種病症及障礙(包括發炎疾病及與中樞神經系統(CNS)之功能障礙有關之疾病)的方法。