The present invention provides cyclohexyl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.本發明提供調節Janus激酶(JAK)之活性且適用於治療與JAK之活性相關之疾病,包括例如發炎性病症、自體免疫性病症、癌症及其他疾病的環己基氮雜環丁烷衍生物以及其組合物及使用方法。