The present disclosure relates to a screw coupling structure for preventing loosening, and more particularly, to a screw coupling structure for preventing loosening for preventing loosening between a screw portion and an engagement portion, which includes the screw portion having a predetermined length and the engagement portion having a screw hole through which the screw portion is inserted and engaged, in which the screw portion is formed of a shape memory alloy deformable by an external force applied thereto at a temperature lower than a predetermined threshold temperature and recoverable from the deformation by heating to a temperature higher than the threshold temperature.