Step of the present invention provides a porous solid substrate The method comprising: generating a coated substrate by coating a coating liquid containing the active polyoxazoline (EL-POX) and a solvent to the substrate with an electrophilic, the EL-POX is containing an at least two reactive electrophilic to produce a coated substrate Comprising the step of removing the solvent from the coated substrate, there is provided a method for producing a hemostatic adhesive products. The method of the present invention so that the ability to make, without substantially damaging the pore structure of the substrate can be covered by the EL-POX coating the porous substrate to absorb body fluids such as blood not essentially affected. The EL-POX coated hemostasis obtained by the method of the present invention the product is, for example, have excellent adhesive properties due to the presence of covalently attached electrophilic reactor to amine groups react to naturally present in the tissue under the form of . The present invention also provides an adhesive hemostatic product selected from the coated mesh, the coated foam and the coated powder, the outer surface of said hemostatic products include nucleophilic polymer containing a reactive nucleophilic has a porosity of at least 5% by volume the porous solid substrate comprising An adhesive coating covering at least a portion of the solid substrate, wherein the coating comprises a poly-oxazoline (EL-POX) activated with an electrophilic, the EL-POX, on average, at least containing a single reactive electrophilic which provides a, hemostatic adhesive product comprising an adhesive coating.본 발명은 다공성 고체 기재를 제공하는 단계 상기 기재를 친전자성으로 활성적인 폴리옥사졸린(EL-POX) 및 용매를 포함하는 코팅액으로 코팅하여 코팅된 기재를 생성하는 단계로서, 상기 EL-POX는 적어도 2개의 반응성 친전자성 기를 함유하는 코팅된 기재를 생성하는 단계 코팅된 기재로부터 용매를 제거하는 단계를 포함하는, 접착 지혈 제품을 제조하는 방법을 제공한다. 본 발명의 방법은 기재의 공극 구조를 대체로 손상시키지 않고 EL-POX 코팅의 적용을 가능하게 하여 다공성 기재가 혈액과 같은 체액을 흡수하는 능력이 본질적으로 영향을 받지 않게 한다. 본 발명의 방법에 의해 수득된 EL-POX 코팅된 지혈
