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CELL COLONIZATION MATRIX
专利权人:
БИОЭНЕРДЖИ КАПИТАЛ АГ (DE)
发明人:
ГЕРНЕ Мартин (DE),КОРДИК Томас (DE)
申请号:
RU2014135278
公开号:
RU2014135278A
申请日:
2013.02.01
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A matrix for cell implants with associated porosity of more than 80%, consisting mainly of a mixture of bioabsorbable polymers, where the matrix has a disk shape, characterized in that the surface on one side of the disk has less than 20% of the average fraction of pores on the other sides of the disk. . The matrix of claim 1, wherein the matrix is hydrophilically coated. 3. The matrix according to claim 2, wherein the coating mainly consists of particles of (meth) acrylic acid. The matrix of claim 2, wherein the coating thickness is more than 1 μm. The matrix according to claim 1, where the matrix mainly consists of poly (α-hydroxy) carboxylic acids. Matrix according to one of paragraphs. 1-5, where the resorption rates of the two polymers forming the mixture, each of which is at least 10% of the mixture, differ by a factor of more than 5.7. A method for producing a matrix for cell implants with various associated porosities, wherein the method comprises: obtaining a bioabsorbable polymer layer; unilaterally layering on the polymer layer a mixture of a water-soluble solid, at least two polymers with different resorption rates and a water-immiscible solvent for at least one of polymers; solvent evaporation; and treating the sinter with water to remove the water-soluble solid from the hardened layer. 8. The method according to claim 7, further comprising applying pressure to compress the mixture after evaporation of the solvent. The method of claim 7, wherein chloroform is used as a solvent. The method of claim 7, wherein the resorption rates of the two polymers forming the mixture, each of which is at least 10% of the mixture, differ by a factor of more than 5.11. The method of claim 7, further comprising coating with a hydrophilizing component after processing1. Матрица для клеточных имплантатов со связанной пористостью более 80%, состоящая в основном из смеси биорассасываемых полимеров, где матрица имеет форму диска, отличающаяся тем, что поверхность на одной с
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