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Derivatives of dolastatin 10 and auristatins
专利权人:
PIERRE FABRE MEDICAMENT
发明人:
Perez, Michel,Rilatt, Ian,Lamothe, Marie
申请号:
NZ71420314
公开号:
NZ714203A
申请日:
2014.04.25
申请国别(地区):
NZ
年份:
2020
代理人:
摘要:
The present invention concerns a compound of following formula (I) where: - R1 is H or OH, - R2 is a (C1-C6)alkyl, COOH, COO-((C1-C6)alkyl) or thiazolyl group, - R3 is H or a (C1-C6)alkyl group, and - R4 is an aryl-(C1-C8)alkyl group substituted by one or more groups chosen from among OH and NR9R10 groups, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and its uses in particular for the treatment of cancer, pharmaceutical compositions containing the same and the preparation methods thereof.
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