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DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS
专利权人:
PIERRE FABRE MÉDICAMENT
发明人:
PEREZ, MICHEL,RILATT, IAN,LAMOTHE, MARIE
申请号:
RSP20171344
公开号:
RS56717B1
申请日:
2014.04.25
申请国别(地区):
RS
年份:
2018
代理人:
摘要:
The present invention concerns a compound of following formula (I) where: &mdashR1 is H or OH, &mdashR2 is a (C1-C6)alkyl, COOH, COO&mdash((C1-C6)alkyl) or thiazolyl group, &mdashR3 is H or a (C1-C6)alkyl group, and &mdashR4 is an aryl-(C1-C8)alkyl group substituted by one or more groups chosen from among OH and NR9R10 groups, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and its uses in particular for the treatment of cancer, pharmaceutical compositions containing the same and the preparation methods thereof.
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