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DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS
专利权人:
发明人:
申请号:
EP14719330.4
公开号:
EP2989087A1
申请日:
2014.04.25
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention concerns a compound of following formula (I) where: &mdashR1 is H or OH, &mdashR2 is a (C1-C6)alkyl, COOH, COO&mdash((C1-C6)alkyl) or thiazolyl group, &mdashR3 is H or a (C1-C6)alkyl group, and &mdashR4 is an aryl-(C1-C8)alkyl group substituted by one or more groups chosen from among OH and NR9R10 groups, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and its uses in particular for the treatment of cancer, pharmaceutical compositions containing the same and the preparation methods thereof.
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