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СПОСОБЫ ПОЛУЧЕНИЯ И ОЧИСТКИ ГЕТЕРОАРИЛЬНЫХ СОЕДИНЕНИЙ
专利权人:
СИГНАЛ ФАРМАСЬЮТИКАЛЗ; ЭлЭлСи (US)
发明人:
ХАРРИС Рой Л. (US),САПИЕНЗА Джон (US),ШЕВЛИН Гразиэлла (US),ПАПА Патрик (US),ЛИ Бренден Джингси (US),ПАКАРД Гаррик (US),ЧЖАО Цзинцзин (US),ДЖОКИЛ Патрик Энтони (US),МОРТЕНСЕН Дебора (US),РИГГС Дженниф
申请号:
RU2012121806/04
公开号:
RU2012121806A
申请日:
2010.10.22
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A process for the preparation of a compound of formula (I) comprising contacting a compound of formula (III) with RY in a solvent in the presence of a palladium catalyst, wherein said contacting occurs under conditions suitable for the preparation of a compound of formula (I) wherein: X is halogen, B (OR) or Sn (R), Y is halogen, triflate, B (OR) or Sn (R) where a) if X beforeis halogen, then Y is B (OR) or Sn (R) or b) when Y is halogen or triflate, then X is B (OR) or Sn (R), wherein each R is independently hydrogen or substituted or unsubstituted C1-6 alkyl or each R together with the boron atom and the atoms to which they are attached, form a cyclic boronate and R & lt 1 & gt is C1-6alkyl and wherein R1 is substituted or unsubstituted C1-6alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heterocyclylalkyl R1 is H, substituted or unsubstituted C1-6alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl,
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