CHESSARI, GIANNI,CONGREVE, MILES STUART,NAVARRO, EVA FIGUEROA,FREDERICKSON, MARTYN,MURRAY, CHRISTOPHER,WOOLFORD, ALISON JO-ANNE,CARR, MARIA GRAZIA,DOWNHAM, ROBERT,O'BRIEN, MICHAEL ALISTAIR,PHILLIPS, T
申请号：
CA2604042
公开号：
CA2604042C
申请日:
2006.04.13
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides compounds of the formula (I):(see formula I)or salts, tautomers, solvates and N-oxides thereof； wherein R1 is hydroxy orhydrogen； R2 ishydroxy； methoxy or hydrogen； provided that at least one of R1 and R2 ishydroxy； le is selectedfrom hydrogen； halogen； cyano； optionally substituted C1-5 hydrocarbyl andoptionally substitutedC1-5 hydrocarbyloxy； R4 is selected from hydrogen； a group -(O)n-R7 where n is0 or 1 and R7 isan optionally substituted acyclic C1-5 hydrocarbyl group or a monocycliccarbocyclic orheterocyclic group having 3 to 7 ring members； halogen； cyano； hydroxy； amino；and optionallysubstituted mono- or di-C1-5 hydrocarbyl-amino； or R3 and R4 together form amonocycliccarbocyclic or heterocyclic ring of 5 to 7 ring members； and NR5R6 forms anoptionallysubstituted bicyclic heterocyclic group having 8 to 12 ring members of whichup to 5 ringmembers are heteroatoms selected from oxygen, nitrogen and sulphur.The compounds have activity as Hsp90 inhibitors.
