Markus RUDOLPH,Daniel HUNZIKER,Holger KUEHNE,Jérôme HERT,Patrizio MATTEI
申请号：
MX2016010675
公开号：
MX2016010675A
申请日:
2015.03.23
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
The invention provides novel compounds having the general formula (I) wherein R1, R2, A1 and A2 are as described herein, compositions including the compounds. These compounds of formula (I) are useful for therapy or prophylaxis in a mammal, and in particular to autotaxin (ATX) inhibitors which are inhibitors of lysophosphatidic acid (LPA) production and thus modulators of LPA levels and associated signaling, for the treatment or prophylaxis of renal conditions, liver conditions, inflammatory conditions, conditions of the nervous system, conditions of the respiratory system, vascular and cardiovascular conditions, fibrotic diseases, cancer, ocular conditions, metabolic conditions, cholestatic and other forms of chronic pruritus and acute and chronic organ transplant rejection.La invención proporciona nuevos compuestos que tienen la fórmula general (I): (ver Fórmula) en la que R1, R2, A1 y A2 tienen el significado aquí descrito, composiciones que incluyen estos compuestos y métodos de uso de los compuestos.
