Memorial Sloan Kettering Cancer Center;Research Foundation of the City University of New York
发明人:
Maria Contel,Natalia Curado,Jason Lewis,Sophie Poty
申请号：
US16503958
公开号：
US20200016276A1
申请日:
2019.07.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Antibody-drug-conjugates (ADC) are provided having a structure of:wherein L is PR3 ligand. The ADC has n drug moieties bound to the Trastuzumab antibody such that the ADC has a drug-to-antibody ratio (DAR) between 2 and 4 and the drug moieties are bound to the Trastuzumab antibody through cysteine (S) or lystine (Lys) residues. The disclosed ADCs are particularly useful in treating breast cancer.
