LERCHEN, HANS-GEORG,里尔彻 汉斯乔治,里爾徹 漢斯喬治,STELTE-LUDWIG, BEATRIX,史泰特路德维格 贝翠克丝,史泰特路德維格 貝翠克絲,GOLFIER, SVEN,高菲尔 斯凡,高菲爾 斯凡,KOPITZ, CHARLOTTE CHRISTINE,科皮兹 夏绿蒂,科皮茲 夏綠蒂,BEIER, RUDOLF,贝尔 鲁道夫,貝爾 魯道夫,EL SHEIKH, SH
申请号：
TW101114207
公开号：
TW201302799A
申请日:
2012.04.20
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target mesothelin, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.本申請書係關於針對標靶間皮素(target mesothelin)之N,N-二烷基奧瑞他汀(N,N-dialkylauristatin)的結合劑-藥物接合物(ADC)、這些ADC之活性代謝物、製備這些ADC之方法、這些ADC於治療及/或預防疾病之用途,以及這些ADC於製造醫藥品供治療及/或預防疾病,特別是過度增生及/或血管新生疾病,例如癌症疾病之用途。此等治療可以單一治療或另與其他的醫藥品或另外的治療方法組合來施行。
