PROCEDE DE SYNTHESE AMELIORE DE LA PIRFENIDONE

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专利权人:

INC.;INTERMUNE

发明人:

RADHAKRISHNAN, RAMACHANDRAN,CYR, MIKE,BOUTET, SABINE MARIE-FRANCOISE BRIGITTE

申请号：

CA2764043

公开号：

CA2764043C

申请日:

2010.06.02

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

A process for synthesizing pirfenidone from bromobenzene having less thanabout 0.15% by weight dibromobenzeis disclosed. Also disclosed are processes of synthesizing pirfenidone withoutusing ethyl acetate or n-butanol, and pirfenidonehaving controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specifiedretention times. Also disclosed are formulated dosage forms including thedisclosed pirfenidone.

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