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Improved method for synthesizing pirfenidone.
专利权人:
INTERMUNE INC
发明人:
RADHAKRISHNAN RAMACHANDRAN,CYR MIKE,BOUTET SABINE MARIE-FRANCOISE BRIGITTE
申请号:
AP2012006052
公开号:
AP2012006052A0
申请日:
2010.06.02
申请国别(地区):
AP
年份:
2012
代理人:
摘要:
A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenzene is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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