The cell of antibody compositions is generated with what, for example, with the antibody with higher antibody-dependant cell cytotoxic activity of the various diseases of what, antibody fragment or fusion protein with antibody Fc functional areas； The method for generating antibody compositions by using these cells； Antibody compositions； And application thereof. In antibody compositions described above, fucose is not integrated to the sugar chain on N-acetylglucosamine in sugar chain reducing end, and the ratio for connecting sugar chain complex with the total N- glucosides for being integrated to the functional areas Fc reaches 20% or higher. Further it is provided that new GDP- mannose 4,6- dehydrogenase, GDP- ketone -6-de-oxy-L-mannose 3,5- epimerase 4- reductase, GDP- β-L-fucose pyrophosphorylase, α -1,6- fucosyltransferase and the DNA for encoding them.用於産生抗體組合物的細胞，例如，用於各種疾病的具有較高抗體依賴細胞毒活性的抗體，具有抗體Fc功能區的抗體片段或融合蛋白；通過採用這些細胞産生抗體組合物的方法；抗體組合物；及其用途。在上面描述的抗體組合物中，岩藻糖不在糖鏈還原端結合到N-乙酰氨基葡萄糖上的糖鏈，與結合到Fc功能區的總N-糖苷連接糖鏈複合體的比率達到20%或更高。此外，提供了新的GDP-甘露糖4,6-脫氫酶、GDP-酮-6-脫氧甘露糖3,5-差向異構酶4-還原酶、GDP-β-L-岩藻糖焦磷酸化酶、α-1,6-岩藻糖基轉移酶及編碼它們的DNA。
