The cell of antibody compositions is generated with what, for example, with the antibody with higher antibody-dependant cell cytotoxic activity of the various diseases of what, antibody fragment or fusion protein with antibody Fc functional areas; The method for generating antibody compositions by using these cells; Antibody compositions; And application thereof. In antibody compositions described above, fucose is not integrated to the sugar chain on N-acetylglucosamine in sugar chain reducing end, and the ratio for connecting sugar chain complex with the total N- glucosides for being integrated to the functional areas Fc reaches 20% or higher. Further it is provided that new GDP- mannose 4,6- dehydrogenase, GDP- ketone -6-de-oxy-L-mannose 3,5- epimerase 4- reductase, GDP- β-L-fucose pyrophosphorylase, α -1,6- fucosyltransferase and the DNA for encoding them.用於産生抗體組合物的細胞,例如,用於各種疾病的具有較高抗體依賴細胞毒活性的抗體,具有抗體Fc功能區的抗體片段或融合蛋白;通過採用這些細胞産生抗體組合物的方法;抗體組合物;及其用途。在上面描述的抗體組合物中,岩藻糖不在糖鏈還原端結合到N-乙酰氨基葡萄糖上的糖鏈,與結合到Fc功能區的總N-糖苷連接糖鏈複合體的比率達到20%或更高。此外,提供了新的GDP-甘露糖4,6-脫氫酶、GDP-酮-6-脫氧甘露糖3,5-差向異構酶4-還原酶、GDP-β-L-岩藻糖焦磷酸化酶、α-1,6-岩藻糖基轉移酶及編碼它們的DNA。