LOO, DERYK, T.,HUANG, LING,CHEN, FRANCINE ZHIFEN,MOORE, PAUL A.,JOHNSON, LESLIE S.
申请号：
EP11751204
公开号：
EP2542256A4
申请日:
2011.03.01
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
