ANTIDEPRESSEUR, NEUROPROTECTEUR, INHIBITEUR DE DEPOT DE BETA-AMYLOIDE E AGENT ANTI-AGE COMPORTANT UN COMPOSE HETEROCYLIQUE AYANT UNE STRUCTURE SPECIFIQUE
The present invention provides an antidepressant, neuroprotectant, amyloid.beta. deposition inhibitor, or age retardantcomposition comprising containing a heterocyclic compound having the generalFormula (I):(see formula I) ..or a pharmaceutically acceptable salt or hydrate thereof. The structural unit(see formula II)being selected from(see formulas III)R1 and R2 each are one or more functional groups independently selected fromthe group consisting of a hydrogenatom, halogen atom, hydroxy group, amino group, acetylamino group, benzylaminogroup, trifluoromethyl group,C1-C6 alkyl group, C1-C6 alkoxy group, and -O-(CH2)n-R3, wherein R5 is a vinylgroup, C3-C6 cycloalkyl group, orphenyl group, and n is 0 or 1. R3 and R4 together form a spiro ring B of thegeneral formula (IV):(see formula IV)The spiro ring B is a structural unit having the general Formula (V) and bindsat a position marked by *in the generalFormulas (V) to form a spiro ring.(see formula V) .......................................R8 is one or more functional groups selected from the group consisting of ahydrogen atom, halogen atom, hydroxygroup, C1-C6 alkoxy group, cyano group, and trifluoromethyl group.
