Antibody variant and isoform with lowered biological activity

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专利权人:

Chugai Seiyaku Kabushiki Kaisha

发明人:

HOSOGUCHI, Kensaku,KUWAYAMA, Maki,SEIDA, Chifumi,WATANABE, Yosuke,TANAKA, Nobuyuki,SAITOH, Satoshi,FUKUDA, Masakazu

申请号：

AU2018361430

公开号：

AU2018361430A1

申请日:

2018.10.31

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

As an antibody variant and isoform having a lower FVIII-like activity than emicizumab, provided are an antibody variant (Q-CDR-clipped variant) in which a specific amino acid residue in a variable region is cleaved and deleted, and an antibody isoform (protected disulfide isoform) in which a disulfide bond between heavy chains is hardly reduced under mild reduction conditions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/