VARIANT D'ANTICORPS ET ISOFORME A ACTIVITE BIOLOGIQUE REDUITE

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA;CHUGAL SEIYAKU KABUSHIKI KAISHA

发明人:

HOSOGUCHI, KENSAKU,KUWAYAMA, MAKI,SEIDA, CHIFUMI,WATANABE, YOSUKE,TANAKA, NOBUYUKI,SAITOH, SATOSHI,FUKUDA, MASAKAZU

申请号：

CA3079053

公开号：

CA3079053A1

申请日:

2018.10.31

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

As an antibody variant and isoform having a lower FVIII-like activity than emicizumab, provided are an antibody variant (Q-CDR-clipped variant) in which a specific amino acid residue in a variable region is cleaved and deleted, and an antibody isoform (protected disulfide isoform) in which a disulfide bond between heavy chains is hardly reduced under mild reduction conditions.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/