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MUTANTE ANTAGONISTA DE ANTICORPO ANTI-CD40
专利权人:
KYOWA HAKKO KIRIN CO.; LTD.
发明人:
NOBUAKI TAKAHASHI,TORU MIURA,YOSHINORI KITAGAWA,AKI HIRANO
申请号:
PT04808100
公开号:
PT1707627E
申请日:
2004.12.24
申请国别(地区):
PT
年份:
2013
代理人:
摘要:
A mutant of a potentially therapeutic anti-CD40 antibody is provided which mutant has reduced ADCC and CDC activities designed to be optimized as a pharmaceutical agent. A mutant of an agonistic anti-CD40 antibody, comprising mutation and/or substitution of at least one amino acid in the constant region to reduce the ADCC and/or CDC activities therein, and a mutant of an antagonistic anti-CD40 antibody, comprising at least one mutation or substitution in the constant region to reduce the ADCC and/or CDC activities therein, both mutants having at least a hinge region derived from a human IgG2.
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