Michael Kauffman;Sharon Shechter;Vincent P. Sandanayaka;Sharon Shacham
发明人:
Sharon Shacham,Michael Kauffman,Vincent P. Sandanayaka,Sharon Shechter
申请号：
US13041377
公开号：
US08513230B2
申请日:
2011.03.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).
