Shacham, Sharon,Kauffman, Michael,Sandanyaka, Vincent P.,Shechter, Sharon
申请号:
AU2011222531
公开号:
AU2011222531B2
申请日:
2011.03.05
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).