Mary Lynn Mercado;Hiroki Hagiwara;Michael Rafii;Mark A. Bowe;Justin R. Fallon;Alison Amenta;Beth McKechnie
发明人:
Justin R. Fallon,Michael Rafii,Mark A. Bowe,Beth McKechnie,Alison Amenta,Mary Lynn Mercado,Hiroki Hagiwara
申请号：
US12786294
公开号：
US08822418B2
申请日:
2010.05.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan； diseases or conditions associated with an abnormal level or activity of collagen VI； disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC)； and disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation.
