Mary Lynn Mercado;Hiroki Hagiwara;Mark A. Bowe;Michael Rafii;Justin R. Fallon;Alison Amenta;Beth McKechnie
发明人:
Justin R. Fallon,Mark A. Bowe,Beth McKechnie,Michael Rafii,Alison Amenta,Mary Lynn Mercado,Hiroki Hagiwara
申请号：
US12881891
公开号：
US08658596B2
申请日:
2010.09.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan； disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC)； disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.
