FORMULATIONS CONTAINING POLY (0-2-HYDROXYETHYL) STARCH FOR INCREASING THE OXYGEN-CONTENT, STABILITY AND SHELF LIFE OF AN ORGAN AND TISSUE PRESERVATION SOLUTION
Organ and tissue preservation solutions having improved formulations. The improved solutions are comprised of two separate solutions. The first solution, is comprised of one or more salts, water, dissolved oxygen, Poly (0-2-hydroxyethyl) starch, lactobionic acid, adenosine, raffinose and allopurinol and said first solution has a pH of at least 7.0, preferably from about 7.3 to about 8.2 and a second solution comprised of water, and reduce glutathione at a pH of below 7.0, preferably from about 3 to 6 wherein oxygen present in the solution is removed. The two formulations are then mixed together at the point of use resulting in the organ and tissue preservation solution having improved stability and that contains oxygen to prevent ischemia in the preserved organs. The present invention is also comprised of kits that contain the two formulations.本發明係關於具有改良調配物之器官及組織保存溶液。該等改良溶液包括兩種單獨溶液。第一溶液包括一或多種鹽、水、溶解氧、聚(0-2-羥乙基)澱粉、乳糖醛酸、腺苷、棉子糖及異嘌呤醇,且該第一溶液具有至少7.0、較佳地約7.3至約8.2之pH;且第二溶液包括水及還原型麩胱甘肽,其pH低於7.0,較佳地為約3至6,其中去除存在於該溶液中之氧。然後,在使用時將該兩種調配物混合在一起,從而得到該器官及組織保存溶液,其具有改良安定性,且其含有氧以防止所保存器官局部缺血。本發明亦包括含有該兩種調配物之套組。10‧‧‧袋12‧‧‧室14‧‧‧室16‧‧‧夾器
