A wound protecting and fixing device includes at least a protecting and fixing layer (1) with an opening. The opening (11) is defined in the protecting and fixing layer and configured to extend between an upper plane and a lower plane of the protecting and fixing layer along a longitudinal direction, and to surround a wound therein so that the protecting and fixing layer (1) with the opening limits an increase of tension at the wound and a movement-incurred wrinkle of skin at the wound. The protecting and fixing layer (1) with the opening includes a flexible protecting and fixing layer (1a) with an opening and a rigid protecting and fixing layer (1b) with an opening. The wound protecting and fixing device can prevent the wound from being ripped and ruptured, and prevent damages to the wound caused by movement-incurred wrinkles of the skin at the wound and relative displacement frictions between the wound, a dressing and a catheter.