A wound protecting and fixing device includes at least a protecting and fixing layer (1) with an opening. The opening (11) is defined in the protecting and fixing layer and configured to extend between an upper plane and a lower plane of the protecting and fixing layer along a longitudinal direction, and to surround a wound therein so that the protecting and fixing layer (1) with the opening limits an increase of tension at the wound and a movement-incurred wrinkle of skin at the wound. The protecting and fixing layer (1) with the opening includes a flexible protecting and fixing layer (1a) with an opening and a rigid protecting and fixing layer (1b) with an opening. The device can prevent the wound from being ripped and ruptured, and prevent damages caused by movement-incurred wrinkles of the skin at the wound and relative displacement frictions.