Ronald Meijboom,Paul Marcel Van Midwoud,Maarten Van Dijk,Theodorus Adrianus Cornelius Flipsen,Esther De Boef
申请号：
US15772992
公开号：
US10508200B2
申请日:
2016.11.04
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A composition including a) 55-98.9 wt % of at least one type of triblock copolymer (A) of formula (1)R—；B-A-B—；R ； ；(1)b) 0.1-15 wt % of at least one surfactant (B) and c) 1-30 wt % of water, wherein A is a hydrophilic block having a number average molecular weight (Mn) of 100-1,000 Da, B is a hydrophobic block made from monomers having at least a monomer B1 and a monomer B2, wherein B1 and B2 have the largest weight contents in the hydrophobic block and B1 has a lower molecular weight than B2, wherein R is an end group which is H or a C1-C30 organic moiety, wherein the composition is fluid in a temperature range of 0° C. to 37° C., wherein the weight % are relative to the sum of a), b) and c), and wherein the sum of components a), b) and c) is at least 80 wt % of the entire composition, preferably at least 90 wt %； to the use of the composition and to pharmaceutical compositions having said composition and an active pharmaceutical ingredient.
