FIELD: pharmaceutics.SUBSTANCE: invention relates to compounds of formula (I) and their pharmaceutically acceptable salts thereof, which have inhibitory effect on cep-dependent endonuclease. In formula (I),PR represents a group selected from -C(=O)-PR0, -C(=O)-PR1, -C(=O)-L-PR1, -C(=O)-L-O-PR1, -C(=O)-L-O-L-O-PR1, -C(=O)-O-PR2, -C(=O)-N(PR2)2, -C(=O)-O-L-O-PR2, -CH2-O-PR3, -CH2-O-L-O-PR3, -CH2-O-C(=O)-PR3, -CH2-O-C(=O)-O-PR3, -CH(-CH3)-O-C(=O)-O-PR3, -CH2-O-C(=O)-N(-K)-PR3, -CH2-O-C(=O)-O-L-O-PR3, -CH2-O-C(=O)-O-L-N(PR3)2, -CH2-O-C(=O)-N(-K)-L-O-PR3, -CH2-O-C(=O)-N(-K)-L-N(PR3)2, -CH2-O-C(=O)-O-L-O-L-O-PR3, -CH2-O-C(=O)-O-L-N(-K)-C(=O)-PR3, -CH2-O-P(=O)(-OH)2, -CH2-O-P(=O)(-OBn)2, -CH2-PR4, -C(=N+PR52)(-NPR52) R1a – hydrogen, halogen, carboxy, lower alkyl, possibly containing substituent C, lower alkyl carbonyl, possibly containing substituent C, or -Z-N(RA1)(RA2), R2a – hydrogen or lower alkyl, possibly containing substituent C R3a – hydrogen, lower alkyl, possibly containing substituent C, a carboxylic group, possibly containing substituent C, carbocycle-lower alkyl, possibly containing substituent C, carbocycloksi-lower alkyl, possibly containing substituent C, heterocyclic group, possibly containing substituent C, or heterocycle-lower alkyl, possibly containing substituent C, or B1, or B2 represents a CR5aR6a, and the other represents a NR7a, or B1 represents a CR8aR9a and B2 represents a CR10aR11a. Values of other radicals are given in the patent claim. Invention also refers to pharmaceutical compositions.EFFECT: obtained new compounds of formula (I) possessing inhibitory activity against the cep-dependent endonuclease and which can be useful in treating influenza.10 cl, 4 dwg, 35 tbl, 1035 exИзобретение относится к соединениям формулы (I) и их фармацевтически приемлемым солям, которые обладают ингибирующей активностью в отношении кэп-зависимой эндонуклеазы. В формуле (I),PR представляет собой группу, выбранную из -C(=O)-PR0, -C(=O)-PR1, -C(=O)-L-PR1, -C(=O)-L-
