Process for the preparation of rosuvastatin salts

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专利权人:

Gyoergyi Kovanyine Lax

发明人:

Gyoergyi Kovanyine Lax,Eva Sipos,Jozsef Barkoczy,Balazs Volk,Gyula Simig,Ferenc Bartha,Gyoergy Ruzsics,Adrienn Karasz,Imre Kiraly,Kalman Nagy

申请号：

US13143943

公开号：

US08507513B2

申请日:

2010.01.15

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methanesulphonyl-methyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated.

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