rosuvastatin salt preparation process

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专利权人:

EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MÜKÖDÖ RÉSZVÉNYTÁRSASÁG

发明人:

ADRIENN KARASZ,BALÁZS VOLK,FERENC BARTHA,GYULA SIMIG,GYÖRGY RUZSICS,IMRE KIRÁLY,JOZSEF BARKÓCZY,KÁLMÁN NAGY,LAX KOVÁNYINÉ,ÉVA SIPOS

申请号：

BRPI1005147

公开号：

BRPI1005147A2

申请日:

2010.01.15

申请国别(地区):

BR

年份:

2019

代理人:

摘要：

The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methanesulphonyl-methyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated.

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