PROBLEM TO BE SOLVED: To provide a medicine that inhibits a plurality of kinases and signals necessary for a cell cycle, cell proliferation or the survival of cancer stem cells, to exhibit an antitumor action, and is highly safe with reduced side effects.SOLUTION: A pharmaceutical composition contains a compound represented by formula (1) or pharmacologically acceptable salt thereof [X is N or CR5 Y is H, C1-6 alkyl or the like R1a-R1e independently represent H, halogen, nitro, C1-6 alkyl or the like R4 is H, cyano, substituted/unsubstituted C1-6 alkyl or the like R2, R3 and R5 independently represent H, halogen, hydroxy, C1-6 alkyl, C3-6 cycloalkyl or the like Ar is C6-10 monocyclic/polycyclic aryl or 5-10 membered monocyclic/polycyclic heteroaryl].SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】細胞周期、細胞増殖または癌幹細胞の生存に必要な、複数のキナーゼ及びシグナルを阻害して、抗腫瘍作用を発揮し、副作用を低減した安全性の高い医薬の提供。【解決手段】式(1)で表される化合物又はその薬理上許される塩を含む、医薬組成物。[XはN又はCR5;YはH、C1-6アルキル等;R1a~R1eは各々独立にH、ハロゲン、ニトロ、C1-6アルキル等;R4はH、シアノ、置換/非置換のC1-6のアルキル等;R2、R3及びR5は各々独立にH、ハロゲン、ヒドロキシ、C1-6のアルキル、C3-6のシクロアルキル等;Arは、C6-10の単環/多環のアリール又は5員~10員の単環/多環のヘテロアリール]【選択図】なし
