Mildred Acevedo-Duncan,Shraddha R. Desai,Hla Yee Win,David A. Ostrov,Prajit P. Pillai,Diondra D. Hill
申请号：
US12210576
公开号：
US08461192B2
申请日:
2008.09.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
PKCiota inhibitor 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-,[1R-(1α,2β,3β,4α)], (ICA-1), targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKCiota and inhibits PKCiota activity. The data shows suprising and unexpected ability of ICA-1 to selectively inhibit the proliferation of cells that overexpress PKCiota.
