MACDONALD LYNN,MURPHY ANDREW J.,MCWHIRTER JOHN,GURER CAGAN,HARRIS FAITH,STEVENS SEAN,VORONINA VERA
申请号：
NZ62345612
公开号：
NZ623456A
申请日:
2012.10.26
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a non-human animal comprising at an endogenous Major Histocompatibility Complex I (MHC I) locus a nucleotide sequence encoding a chimeric human/non-human MHC I polypeptide, wherein a human portion of the chimeric polypeptide comprises &alpha；1, &alpha；2, and &alpha；3 domains of a human MHC I polypeptide, and wherein the non-human animal expresses the chimeric human/non-human MHC I polypeptide.
