Julie Ann Spicer,William Alexander Denny,Christian Karl Miller,Patrick David OConnor,Kristiina Huttunen,Joseph A. Trapani,Geoff Hill,Kylie Alexander
申请号：
US14422498
公开号：
US09896443B2
申请日:
2013.08.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compounds of formula (1a) and pharmaceutically acceptable salts, solvates, and hydrates thereof and related methods of modulatin perforin activity on a cell: wherein Ring A is selected from a 6-10 membered aryl, 5-6 membered cycloalkyi, 5-6 membered heteroaryl or 5-6 membered heterocyclyl, wherein the heteroaryl and heterocyclyl rings comprise at least one heteroatom selected from N, O or S and wherein the aryl, cycloalkyi, heteroaryl or heterocyclyl rings are optionally substituted with 1 to 3 substituents selected from halo, nitro, —C1-Cealkyl, —C1-Ceaminoalkyl, —C1-C6hydroxyalkyl, -haloC1-C6alkyl, —C1-C6alkoxyl, -haloC1—C
