SPICER, JULIE ANN,DENNY, WILLIAM ALEXANDER,MILLER, CHRISTIAN KARL,OCONNOR, PATRICK DAVID,HUTTUNEN, KRISTIINA,TRAPANI, JOSEPH A.,HILL, GEOFF,ALEXANDER, KYLIE
申请号：
EP13830653
公开号：
EP2888251A4
申请日:
2013.08.21
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Compounds of formula (1a) and pharmaceutically acceptable salts, solvates, and hydrates thereof and related methods of modulatin perforin activity on a cell: wherein Ring A is selected from a 6-10 membered aryl, 5-6 membered cycloalkyi, 5-6 membered heteroaryl or 5-6 membered heterocyclyl, wherein the heteroaryl and heterocyclyl rings comprise at least one heteroatom selected from N, O or S and wherein the aryl, cycloalkyi, heteroaryl or heterocyclyl rings are optionally substituted with 1 to 3 substituents selected from halo, nitro, &mdashC1-Cealkyl, &mdashC1-Ceaminoalkyl, &mdashC1-C6hydroxyalkyl, -haloC1-C6alkyl, &mdashC1-C6alkoxyl, -haloC1&mdashC
