SPICER, JULIE ANN,DENNY, WILLIAM ALEXANDER,MILLER, CHRISTIAN KARL,OCONNOR, PATRICK DAVID,HUTTUNEN, KRISTIINA,TRAPANI, JOSEPH A.,HILL, GEOFF,ALEXANDER, KYLIE
申请号：
CA2881357
公开号：
CA2881357A1
申请日:
2013.08.21
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Compounds of formula (la) and pharmaceutically acceptable salts, solvates, and hydrates thereof and related methods of modulatin perforin activity on a cell: wherein Ring A is selected from a 6-10 membered aryl, 5-6 membered cycloalkyi, 5-6 membered heteroaryl or 5-6 membered heterocyclyl, wherein the heteroaryl and heterocyclyl rings comprise at least one heteroatom selected from N, O or S and wherein the aryl, cycloalkyi, heteroaryl or heterocyclyl rings are optionally substituted with 1 to 3 substituents selected from halo, nitro, -C1-Cealkyl, -C1-Ceaminoalkyl, -C1-C6hydroxyalkyl, -haloC1-C6alkyl, -C1- C6alkoxyl, -haloC1-C
