PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS

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专利权人:

VERTEX PHARMACEUTICALS INCORPORATED

发明人:

ANDERSON, COREY,HADIDA-RUAH, SARA, SABINA,GOLEC, JULIAN MARIAN, CHARLES,ZHANG, BEILI,LITTLER, BENJAMIN, JOSEPH,KESHAVARZ-SHOKRI, ALI,ALCACIO, TIM, EDWARD,BELMONT, DANIEL, T.

申请号：

PH12016501028

公开号：

PH12016501028A1

申请日:

2016.06.01

申请国别(地区):

PH

年份:

2016

代理人:

摘要：

The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

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