Andrew Tasker;Kelvin K. C. Sham;Shimin Xu;Liping H. Pettus
发明人:
Liping H. Pettus,Kelvin K. C. Sham,Andrew Tasker,Shimin Xu
申请号：
US12681823
公开号：
US08314131B2
申请日:
2008.09.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention comprises a new class of compounds useful for modulating the activity of p38 MAP kinase. The compounds have a general Formula Iwherein A1, A2, A3, A4, A5, A6, R1 and R5 are defined herein. The invention further provides pharmaceutical compositions including one or more compounds of Formula I, use of such compounds and compositions for treatment of p38 MAP kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
