Michellys, Pierre-Yves,Pei, Wei,Marsilje, Thomas H.,Chen, Bei,Uno, Tetsuo,Jin, Yunho,Jiang, Tao
申请号：
ES10007914
公开号：
ES2559528T3
申请日:
2007.11.20
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound having Formula (1): ** Formula ** or pharmaceutically acceptable salts thereof； where W is； ** Formula ** A1 and A4 are independently C； each A2 and A3 is C； R1 and R2 together form an optionally substituted 5-6 membered aryl or a heteroaryl or heterocyclic ring comprising 1-3 nitrogen atoms； R3 is SO2R12, SO2NH2, SO2NRR12, CONRR12, CO1-2R12 or cyano； R5, R5, R7 and R10 are independently H； R is H or C1-6 alkyl； R6 is OR12； R8 and R9 are independently C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halo or X, or one of R8 and R9 is H； and with the proviso that one of R8 and R9 is X； X is (CR2) qY, cyano, C (O) O0-1R12, CONR (R12), CONR (CR2) pNR (R12), CONR (CR2) pOR12, CONR (CR2) pSR12, CONR (CR2) pS (O ) 1-2R12 or (CR2) 1-6NR (CR2) pOR12； Y is an optionally substituted 3-12 membered carbocyclic ring, a 5-12 membered aryl or a 5-12 membered heterocyclic or heteroaryl ring comprising N, O and / or S and is attached to A2 or A3 or both by a carbon atom of said heteroaryl or heterocyclic ring when q in (CR2) qY is 0； R12 is C1-6 alkyl； and n is 0； and p and q are independently 0-4 wherein the substituent or optional substituents in each optionally substituted group are selected from C 1-6 alkyl, C 2-6 alkenyl or C 3-6 alkynyl, each of which may be optionally halogenated or optionally a carbon that can be replaced or substituted with N, S, O or a combination thereof； halo, amino, amidino, C1-6 alkoxy, hydroxy, methylenedioxy, carboxy； C1-8 alkylcarbonyl, C1-8 alkoxycarbonyl, carbamoyl, C1-8 alkylcarbamoyl, sulfamoyl, cyano, oxo, nitro, or a carbocyclic ring, heterocyclic ring, aryl or heteroaryl.Un compuesto que tiene Fórmula (1):**Fórmula** o sales farmacéuticamente aceptables del mismo； en la que W es；**Fórmula** A1 y A4 son independientemente C； cada A2 y A3 es C； R1 y R2 juntos forman un arilo de 5-6 miembros opcionalmente sustituido o un anillo heteroarilo o heterocíclico que comprende de 1-3 átomos de nitrógeno； R3 es SO2R12, SO2NH2, SO2NRR12, CONRR12, CO1-2R1
