JAMES D. STOESZ,ALEXIS S. STATHAM,MYHANH T. TRUONG
申请号：
HRP20120128
公开号：
HRP20120128T1
申请日:
2012.02.07
申请国别(地区):
HR
年份:
2012
代理人:
摘要：
A pharmaceutical composition comprising an active substance selected from the group consisting of imiquimod (1-(2-methylpropyl)-1 H -imidazo[4,5- c ]quinolin-4-amine), sotirimod(2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine) and resiquimod (4-amino-±,±-dimethyl-2-ethoxymethyl-1H-imidazo[4,5-c]quinoline-1-ethanol), that is stable to sterilization and suitable for topical application directly to tissue sites where the dermis has been breached, and has been sterilized, packaged compositions that have been sterilized, and methods of sterilizing these compositions are disclosed.Topikalni farmaceutski pripravak koji sadrži spoj sa svojstvom modifikacije imunosnog odgovora stabilan na sterilizaciju i prikladan za topikalnu primjenu izravno na mjesta na tkivima gdje je došlo do pucanja derme； naznačen time, da je to spoj 1-(2-metilpropil)-1H-imidazo[4,5-c]kinolin-4-amin (imikvimod) koji je steriliziran izlaganjem radijaciji s elektronskim snopom. Patent sadrži još 29 patentnih zahtjeva.
