STOESZ, JAMES D.,STATHAM, ALEXIS S.,TRUONG, MYHANH T.,STOESZ, James D.,STATHAM, Alexis S.,TRUONG, Myhanh T.
申请号：
RSP20120043
公开号：
RS52120B
申请日:
2007.07.19
申请国别(地区):
RS
年份:
2012
代理人:
摘要：
A pharmaceutical composition comprising an active substance selected from the group consisting of imiquimod (1-(2-methylpropyl)-1 H -imidazo[4,5- c ]quinolin-4-amine), sotirimod(2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine) and resiquimod (4-amino-±,±-dimethyl-2-ethoxymethyl-1H-imidazo[4,5-c]quinoline-1-ethanol), that is stable to sterilization and suitable for topical application directly to tissue sites where the dermis has been breached, and has been sterilized, packaged compositions that have been sterilized, and methods of sterilizing these compositions are disclosed.Lokalna farmaceutska kompozicija koja sadrži modifikator imunog odgovora kao lekovito jedinjenje koje je stabilno pri sterilizaciji i pogodno za lokalnu primenu direktno na mesta na tkivu gde je dermis oštećen；naznačena time, što je lekovito jedinjenje 1-(2-metilpropil)-l-H-imidazo[4,5-c]hinolin-4-amin (imikuimod), sterilizovan izlaganjem zračenju elektronskog snopa.Prijava sadrži još 29 patentnih zahteva.
